首页> 外文OA文献 >新生児マウス鼻腔への微生物抽出液の投与は気道中のオプソニン量及び、成熟CD1c+ 細胞を増加させる
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新生児マウス鼻腔への微生物抽出液の投与は気道中のオプソニン量及び、成熟CD1c+ 細胞を増加させる

机译:向新生小鼠的鼻腔施用微生物提取物增加呼吸道和成熟CD1c +细胞中调理素的量

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摘要

Nasal exposure to the mixture of microbial extracts (MME) after ablactation enhanced airway resistance of newborn mice to Streptococcus pneumoniae (J Physiol Lung Cell Mol Physiol 298: L67, 2010). The present study was addressed to elucidate effective factors responsible for the enhanced innate resistance in the airway of MME-exposed newborn mice. MME exposure significantly increased the amount of pulmonary surfactants (SP-A and SP-D) in the airway. Bronchoalveolar lavage fluid of the exposed mice exhibited greater levels of opsonic activity, thereby enhancing the phagocytic and intracellular killing activities of alveolar macrophages (MØ) against S. pneumoniae. The exposure itself did not increase a complement component C3 and mannan-binding lectin-A (MBL-A) in the airway, whereas intratracheal infection with S. pneumoniae increased the quantity of SP-A, SP-D, C3, and MBL-A in the exposed mice to a significant extent compared with control mice. The exposure enhanced the expression of the class A scavenger MØ receptor with collagenous structure on alveolar MØ and also increased the frequency of major histocompatibility complex II+ CD11c+ cells in the lung; the cells were able to produce IL-10 and transforming growth factor-β in vitro. These results suggest that microbial exposure early in life increases the amounts of SP-A and SP-D and the number of scavenger MØ and also promotes maturation of CD11c+ cells in the airway of newborn mice, which may be involved in airway resistance to S. pneumoniae.
机译:消融后鼻腔暴露于微生物提取物(MME)的混合物增强了新生小鼠对肺炎链球菌的气道抵抗力(《生理肺细胞生物学杂志》 298:L67,2010)。本研究致力于阐明引起MME暴露的新生小鼠气道中先天性抵抗力增强的有效因素。 MME暴露显着增加了气道中肺表面活性物质(SP-A和SP-D)的量。暴露小鼠的支气管肺泡灌洗液表现出更高水平的调理活性,从而增强了肺泡巨噬细胞(MØ)对肺炎链球菌的吞噬和细胞内杀伤活性。暴露本身并未增加呼吸道中的补体成分C3和甘露聚糖结合凝集素A(MBL-A),而气管内感染肺炎链球菌会增加SP-A,SP-D,C3和MBL-与对照小鼠相比,暴露的小鼠中的A在很大程度上。暴露增强了肺泡MØ上具有胶原结构的A类清道夫MØ受体的表达,并增加了肺中主要组织相容性复合物II + CD11c +细胞的频率;细胞能够在体外产生IL-10和转化生长因子-β。这些结果表明,生命早期暴露于微生物会增加SP-A和SP-D的数量以及清除剂MØ的数量,还促进新生小鼠气道中CD11c +细胞的成熟,这可能与气道对S的抗性有关。肺炎

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