Exocrine Pancreatic Neoplasms in the Mummichog (Fundulus heteroclitus) from aCreosote-Contaminated Site

摘要

A high prevalence of exocrine pancreatic neoplasms occurred in mummichog,Fundulus heteroclitus, from a creosote-contaminated site in the Elizabeth River, Virginia. A total of 20 neoplasms occurred in a group of about 1100 fish evaluated histologically. Of 240 adult fish collected during October 1991, 3.3% had pancreatic neoplasms. Adjusted total lesion prevalence for fish belonging to size classes III and IV was 6.7%. Pancreatic neoplasms were not observed in 234 fish collected at this site during May 1991, nor were pancreatic tumors found in 420 fish examined from 7 other localities. Lesions involved both mesenteric and intrahepatic exocrine pancreas and ranged from well-differentiated acinar cell adenomas to poorly differentiated acinar cell carcinomas.