Sodium Bromate: Short Term Reproductive and Developmental Toxicity Study WhenAdministered to Sprague-Dawley Rats in the Drinking Water. Final Report

摘要

The potential toxicity of sodium bromate (CAS No. 7789-38-0) was evaluated usinga short-term reproductive and developmental toxicity screen. This study design was selected to identify the process (development; female reproduction; male reproduction; various somatic organs/processes) that is the most sensitive to sodium bromate exposure. A dose range-finding study was conducted at concentrations of 0, 250, 500, 1000, and 2000 ppm in order to select concentrations for the 35-day study. Based on dose-related body weight reductions and decreased feed and water consumption, the concentrations for the 35-day study were selected to be 0, 25, 80, and 250 ppm. For the main study, Sprague-Dawley rats were administered sodium bromate at these concentrations in the drinking water over a 35-day period. One group of male rats (10 per group) and two groups of female rats designated as Group A (peri-conception, 10 per group) and Group B (gestational exposure, 13 per group) were used at each dose level. Control animals received deionized water, the vehicle.