Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (CAS No. 1313-27-5)in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

摘要

Molybdenum is an essential element for the function of nitrogenase in plants andas a cofactor for enzymes including xanthine oxidoreductase, aldehyde oxidase, and sulfide oxidase in animals. Molybdenum trioxide is used primarily as an additive to steel and corrosion-resistant alloys. It is also used as a chemical intermediate for molybdenum products; an industrial catalyst; a pigment; a crop nutrient; components of glass, ceramics, and enamels; a flmae retardant for polyester and polyvinyl chloride resins; and a reagent in chemical analyses. Molybdenum trioxide was nominated by the NCI for toxicity and carcinogenicity studies as a representative inorganic molydenum compound. The production of molybdenum trioxide is the largest of all the molybdenum compounds examined.