Study of the Feasibility of Research on Pathologic Types of Lung Cancer in Silica- and Radon-Exposed Miners, Final Report

摘要

The aim of this report was to determine whether post mortem materials stored in alarge German autopsy archive could be used for research on how exposure to silica dust, or the presence of silicosis, influences pathologic characteristics of lung cancer in humans. The sample collected was selected from all those potentially available so as to generate as wide a range as possible of exposures to silica dust and to ionizing radiation. Estimates of cumulative exposures to silica, radon, arsenic, and asbestos were correlated. The patterns of joint distributions of occupational exposures suggest that appropriate further sampling from the autopsy archive can provide data that could be used to test the underlying research hypothesis.