Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals. Volume 1 of 2

摘要

This report summarizes the results of the July 25, 2000 independent scientific peer review panel evaluation of the revised Up-and-Down Procedure (UDP), a method proposed as a substitute for the existing LD50 test for assessing the acute oral toxicity potential of chemicals. The meeting was organized by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and sponsored by the National Institute of Environmental Health Science (NIEHS) and the NTP. The Peer Review Panel evaluated the usefulness of the UDP as an alternative to the conventional LD50 test method for acute oral toxicity currently accepted by regulatory authorities. Federal Register notices relevant to the meeting include a Request for Data and Nomination of Expert Scientists (NIEHS, 2000a) and Notice of Peer Review Meeting and Request for Comments (NIEHS, 2000b). This introduction briefly summarizes the purpose and history of acute toxicity testing and the purpose and conduct of the July 25, 2000 meeting. The remaining parts of this section summarize the UDP Peer Panel's discussions, conclusions, and recommendations from the July 25, 2000 meeting.