Gene-Environment Interactions: PCB Exposures and Adverse Effects on Pregnancy.

摘要

Epidemiologic studies have linked prenatal exposure to polychlorinated biphenyls (PCBs) with adverse neurobehavioral, immunologic, and reproductive effects. While there is substantial evidence that PCBs can interfere with both aryl hydrocarbon receptor and estrogen receptor signaling pathways, our understanding of the molecular mechanisms underlying the effects of prenatal PCB exposures is limited.