Acute Cardiovascular Effects of Maytansine Following Single Bolus Intravenous Injections to Anesthetized Beaglehounds.

摘要

Effects of Maytansine on the ECG,vascular pressures and resistances,cardiac output,and left ventricular contractility were studied on healthy beaglehounds anesthetized with Innovar-pentobarbital. Single,intravenous bolus injections of placebo,and boluses of 0.06, 0.12, 0.24,and 0.48 Maytansine mg/kg body weight were given. Records were obtained during 2pretest periods,and at 5, 20, 40and 60minutes post injection. No changes of physiologic significance in any parameter either measured or computed were produced at any dose level. Although mean pulmonary trunk pressures and systemic arterial resistance increased slightly but statistically significantly,these changes could not be considered of physiologic significance.