Models for Enhancement of Mutagenic and/or Toxic Reactions by Active Inhaled Metallic Inorganic Particles

摘要

It is observed that the biological activity of inhaled aerosols containing metallic particles and insoluble or slightly soluble metal inorganic compounds appears to depend on their physical as well as chemical properties. A series of possible mechanisms is proposed based on 'non-chemical' (i.a. non-ionic) properties especially the existance of crystalline and active surfaces. Such models have significant implications concerning the required sensitivity and design criteria of suitable in vitro experiments to determine possible mutagenic and/or carcinogenic properties of various substances which can remain within the organism for long periods of time: e.g. the aerosols found in the metal working industry. (Copyright (c) The Danish Welding Institute, 1978.)