Thirteen Week Subchronic Toxicity Studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 Dyes, (NCI-CG-TR-108)

摘要

This report presents the results of I3-week subchronic toxicity studies of direct blue 6, direct black 38, and direct brown 95 dyes conducted for the Carcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute (NCl) , National Institutes of Health, Bethesda, Maryland. These sUBchronic studies were conducted as part of the bioassay protocol to establish concentrations for use in 2-year bioassays of the test chemicals in rats and mice. In view of the resul ts obtained in the 13-week studies, the 2-year bioassays will not be performed. The Carcinogenesis Testing Program is designed to determine whether selected chemicals have the capacity to produce cancer in animals. Negative results, in which the test animals do not have a greater incidence of cancer than control animals, do not necessarily mean that the test chemical is not a carcinogen, inasmuch as the experiments are conducted under a limited set of circumstances. Positive results demonstrate that the test chemical is carcinogenic for animals under the conditions of the test and indicate that exposure to the chemical is a potential risk to man. The actual determination of the risk to man from animal carcinogens requires a wider analysis.