Determination of the Effects of Material from Alternate Energy Sources on the Upper Respiratory Tract Clearance Mechanism. Part I: In vitro Exposure to Particulate Pollutants. Part II: In vivo Exposure to Ozone

摘要

Studies were conducted to measure the toxic effects of a variety of substances from the environment on the clearance mechanism of the upper respiratory tract using an in vitro hamster model system. Studies using hamsters for in vivo exposures to ozone were also conducted to determine the effects of ozone on the cilia beat frequency and cytopathology of the tracheal epithelium. Organ cultures of hamster tracheal tissue were exposed to graded concentrations of pollutants to determine effects on the respiratory cilia. Parameters studied were beat frequency, ciliostasis, cytopathology, and ATP concentration.