Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Volume 1. Anticholinesterases and Anticholinergics

摘要

The Department of the Army asked the National Academy of Science to conduct a study of the possible chronic adverse health effects on servicemen of experimental exposure to various chemicals at U.S. Army Laboratories at Edgewood, Maryland, in about 1958-1975. The Edgewood tests were conducted to learn how specific chemicals may affect humans. Some 6,720 soldiers took part in the program; 254 chemicals were administered by various routes. Chemicals were tested for various military applications. The charge to the two panels was to determine whether, on the basis of the data available, it is possible to demonstrate the likelihood of long-term health effects or delayed sequelae and, if so, whether the involved chemicals, as tested, were likely to produce long-term health effects or delayed sequelae. The report is the first of two on the Edgewood tests. It presents the two panels' tentative conclusions which are based on a review of data obtained from Edgewood, on mortality data organized by the NRC Medical Follow-up Agency, and on separate discussions and papers generated by Panel members.