Inhibition of Gap-Junctional Intercellular Communication between Chinese Hamster Lung Fibroblasts by Di (2-Ethylhexyl) Phthalate (DEHP) and Trisodium Nitrilotriacetate Monohydrate (NTA)

摘要

Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals. (Copyright (c) 1989 Princeton Scientific Publishing Co.)