Varicella Zoster Virus Meningitis Complicating Sodium Stibogluconate Treatment for Cutaneous Leishmaniasis

摘要

U.S. Armed Forces, with more than 700 cutaneous cases diagnosed in servicemen deployed in support of Operation Iraqi Freedom. Treatment options available for patients infected with Old World cutaneous leishmaniasis range from observation for patients with mild disease to the administration of parenteral sodium stibogluconate for patients with more significant lesions. Sodium stibogluconate is known to result in several predictable side-effects including arthralgias/ myalgias (58%), elevated pancreatic enzymes (97%), elevated liver-associated enzymes (67%), headache (22%), and hematologic suppression (44%). Herpes zoster temporally associated with the administration of sodium stibogluconate has also been reported, perhaps secondary to transient lymphopenia. In this report, we describe a patient who developed aseptic meningitis and herpes zoster secondary to varicella zoster virus (VZV).