Improved risk estimates for carbon tetrachloride. Project status report and technical progress report

摘要

Carbon tetrachloride (CCl(sub 4)) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl(sub 4) at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl(sub 4). Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl(sub 4) in F344/Crl rats. B6C3F(sub 1) mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl(sub 4) by rats, mice, hamsters, and man. Dose-response relationships will be determined in all these studies. This information will be used to improve the physiologically based pharmacokinetic (PBPK) model for CCl(sub 4) originally developed by Paustenbach et al. (1988) and more recently revised by Thrall and Kenny (1996). The authors will also provide scientific evidence that CCl(sub 4), like chloroform, is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation.