Synthesis of New Vinyl Monomers for Chemical Agent Sensing Applications

摘要

The synthesis of styrene momomer p-vinylbenzoylacetophenone (monomer i) has been carried by the acetylation of 2- chloroethylbenzene and base elimination of the resulting 4-acetyl-2-chloroethylbenzene to give 4- acetylstyrene. This monomer was benzoylated by a sodium hydride mediated Claisen reaction with excess ethylbenzoate to give the monomer 1. This monomer that is of interest in ARO in sensing applications was characterized by proton NMR and by mass spectrometry. Each of the three steps was optimized to give an overall yield of about 35 percent from the starting products. A large amount (50 grams of this monomer) was synthesized and shipped to Dr. Amanda Jenkins.