Fox Chase Cancer Center Institutional Breast Cancer Training Program (FCCC-IBCTP)

摘要

The present report covers the work performed by four different trainees working in: i. - The functional role of chromosomes 11, 13, 14 and 17 in the process of immortalization, transformation and tumorigenesis of human breast epithelial cells. This study has concluded that the chromosome 17 (p13.1- 13.2) region may contain gene/s controlling programmed cell death, and that the tumorigenic phenotype is associated with alterations at different loci of chromosome 13. ii. - Lymphedema Prevention in Breast Cancer Survivors. This study has developed guidelines related to lymphedema prevention among early stage breast cancer survivors to determine the feasibility of the study questionnaire and to determine the most appropriate and effective recruitment approach. Iii - Roles of gamma-synuclein in breast cancer progression and metastasis. The data indicate that gamma-synuclein may promote tumorigenesis by enhancing cell motility through modulating Rho/Rac/Cdc42 and ERK pathways, and promoting cell survival and inhibiting apoptosis through modulating ERK cell survival and JNK-mitochondria-caspase9/3. iv. Polymorphisms of Human UGT1A6 and UGT1A9 Genes and Functional Differences of the Variant Gene Products. This study is aimed at defining whether these putative SERM inactivating enzymes have genetic variations that result in predictable phenotypes at both the molecular level and in the patient.