Computational Modeling of the Prostate-Expressed Lysophosphatidic Acid Receptor Edg-7

摘要

Recently it was shown that the lysophosphatidic acid (LPA) receptor LPA3/EDG7 is expressed in human prostate cancer cell lines namely LNCap and Du- 145. Based on these findings and evidence that LPA is a very potent mitogen, the overall goal of this proposed research is to rationally design LPA3/EDG7 selective ligands. We have identified the probable binding position of two LPA1/ EDG2 and LPA3/EDG7 selective inhibitors namely DGPP (8:0) and FAP (12:0). The binding position and the critical amino acids involved in interacting with these inhibitors relative to the endogenous ligand LPA (18:1) is discussed.