Scaling Relationships for Biomolecules Adhesion and Activity on Polymeric Surfaces

摘要

The project focused on the understanding and engineering quantification of the attachment of biomolecules and cells on polymeric surfaces. The project delivered design tools and guidelines that can be used in the process of design, fabrication and operation of microfluidics devices, in particular plastic-based devices. The project comprised modeling/simulation and experimental modules. The classification results are contained in an online freely accessible database, http://www.bionanoeng.com/bad. This biomolecular adsorption database has over 500 entries, and has been utilized by -1000 clients/month (40% edu, 30% com & 20% gov). A modeling capability for protein adsorption on polymeric surfaces has also been developed. Experiments, based on atomic force microscopy, were conducted to measure forces between biomolecules. The database, combined with the experimental results and the modeling capability will allow for improved design of microfluidic devices.