Investigating Non-Invasive Hemodynamic Monitoring Devices Using Severe Dengue as a Surrogate for Trauma-Induced Shock.

摘要

Dengue viral infection is prevalent throughout tropical and sub-tropical regions of the world. Disease presentation ranges from self-limited fever to life-threatening dengue hemorrhagic fever. This study assessed the use of near infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO2), muscle pH, and continuous arterial waveforms to predict which subjects would develop severe disease. Children ages 6 months to 15 years of age admitted to the hospital with suspected dengue were enrolled. Children were monitored daily for a variety of laboratory values and assessments of volume status in addition to waveform monitoring and NIRS. Results demonstrate that a cardiac reserve index calculated from arterial waveforms and to a less demonstrable extent, muscle pH and Sm02 correlated with fluid status and fluid resuscitation efforts. Further algorithm analysis, evolution of measurement technique and study of these tools in adults may provide useful information in the management of patients diagnosed with dengue virus infection.