Implementing Material Surfaces with an Adhesive Switch.

摘要

The work focuses on implementing material surfaces that present temporal adhesive cues. We are exploring conformational changes in surface-immobilized oligonucleotides to promote an "off-on" switch in adhesion events on the surface of colloidal particles. The overall objective is to optimize oligonucleotide characteristics (e.g. base length, modified nucleotide content, etc.) for chemically-robust macromolecules in order to tailor both the timing as well as extent of reversible adhesion between material surfaces. The long term goal is to design materials with unprecedented abilities to dynamically direct interactions with its surrounding environment.