Targeting Breast Cancer by Active Immunotherapy: Chemical Synthesis of Multiantigenic Unimolecular Antitumor Vaccines

摘要

The goal of developing methodology for the synthesis of carbohydrate antigens has been accomplished on the example of HIV antigens. The goal of developing methodology for incorporation of carbohydrates onto a peptidic backbone and construction of a unimolecular vaccine candidate has been accomplished. The divalent antigen structure was shown to be crucial for binding to an anti HIV antibody 2G12. The synthesis of cancer specific carbohydrate antigens and the work on construction of unimolecular anticancer vaccine are currently in progress.