Corrective In-111 Capromab Pendetide SPECT Image Reconstruction Methods for Improved Detection of Recurrent Prostate Cancer

摘要

It is generally recognized that In-111 capromab pendetide (PS) scans are technically challenging to perform and interpret, particularly with regard to pelvic SPECT studies used to detect possible disease in the prostate fossa and pelvic lymph node (LN). The hypothesis of this proposal is that the superior spatial resolution, high image contrast, and much reduced image artifacts that result from the corrective SPECT image reconstruction methods would substantially aid in the detection and diagnosis of prostate cancer, To test our hypothesis, we propose five specific aims: (1) to develop simulation tools and methods that allow efficient generation of accurate In-111 PS projection data from the human pelvic area, (2) to study the effects of 3D image degrading factors on In PS SPECT images, (3) to develop 3D corrective image reconstruction methods for In-111 PS SPECT that provide much improved image quality and quantitative accuracy by incorporating models of the 3D image degrading factors, (4) to evaluate the 3D corrective image reconstruction methods for clinical In-111 PS SPECT studies using simulated patient data, and Hotelling and human observer studies, and (5) to evaluate the clinical efficacy of the corrective image reconstruction methods as applied to In-111 PS SPECT using patient data.