Breast Cancer Risk in Relation to Urinary Estrogen Metabolites and Their Genetic Determinants: A Study Within the Dutch 'DOM' Cohort

摘要

Purpose and scope: we are conducting a large case-control study nested within the Dutch DOM prospective cohort to estimate relative risk of breast cancer in post-menopausal women by levels of urinary estrogens and estrogen metabolites. Progress report: in this year of extension of the project we finalized the setting up of our sensitive NCI GC/MS method for the measurement of estrogen metabolites in urine samples. By using this method we performed these measurements on 145 breast cancer cases and 145 matched controls. Conclusions: On the first set of data concentrations of 2-hydroxy estrone 2-methoxy estrone and the ratio between 2-hydroxy estrone and 16-alpha hydroxy estrone were significantly associated with breast cancer risk in post- menopausal women. We plan to complete the analyses on the samples from the whole nested case-control study by April 2007 (i.e. beyond the extension limits of this grant and using internal IARC funds). A manuscript will then be prepared reporting the relationships of the urinary hormone levels with breast cancer risk.