Creatine Kinase Clinical Considerations: Ethnicity, Gender and Genetics.

摘要

Exertional rhabdomyolysis (ER), or breakdown of skeletal muscle during exercise, is a potentially life-threatening event. ER can affect Warfighters in multiple settings, yet approaches for identifying persons susceptible to or at risk for ER have not been identified. Despite marked variability in baseline serum creatine kinase (CK), individual CK values are typically used to both diagnose and manage ER. Factors that may affect CD include ethnicity, gender, and genetics. One candidate gene for CK levels is the interleukin-6 (IL-6) gene, which codes for the cytokine, IL6. The purpose of this study was to investigate the contributions of ethnicity, gender, and genetics, in particular the IL-6 polymorphism, to variability in baseline CK. Baseline blood samples were obtained for measuring serum CK and genomic DNA was extracted from peripheral blood leukocytes to genotype participants for the C- 174G IL-6 polymorphism. Among the cohort of 841 men and women, 610 were Caucasians/CA; 44 African Americans/AA; 17 Asians/AS; and 36 Hispanics/HI, with a mean age of 22.8 b4.9 years. Mean baseline CK for this population was 212 546 (SD) U/L, with a minimum of 20 and maximum of 9,500 U/L. Mean CK was significantly higher in African Americans.