Telomere Length Polymorphisms: A Potential Factor Underlying Increased Risk of Prostate Cancer in African American Men and Familial Prostate Cancer. Addendum

摘要

This project tested the hypotheses that inherited and/or acquired differences in telomere length prostate cancer observed in (i) African Americans compared to Caucasians and (ii) affected member (HPC) families. Telomere content, determined by quantitative PCR, in genomic DNA isolated from was assessed for associations with either racial background or prostate cancer in HPC families. isolated blood-derived genomic DNA from 289 members of 39 HPC families, 160 anonymous cord blood of different racial backgrounds and 99 samples from black and white males at mid-life. Analyses on these genomic DNA samples reveals that (i) affected individuals in HPC families tend to have a than the mean telomere lengths of unaffected family members, however, in a subset of families in affected individuals; (ii) no significant differences in telomeres were observed when comparing birth or at mid-life. These results indicate a potential association between telomere length development in a subset of hereditary prostate cancer families, but no evidence of association prostate cancer disparity between black and white males.