Development of Prior Image-Based, High-Quality, Low-Dose Kilovoltage Cone Beam CT for Use in Adaptive Radiotherapy of Prostate Cancer. Annual Summary Report April 15, 2010-April 14, 2011

摘要

Adaptive radiotherapy(RT) is an advanced technique for prostate cancer treatment which employs kilovoltage(KV) cone-beam(CT) (CBCT) for guiding treatment. High quality CBCT images are important in achieving improved treatment effect, but they also require a non-negligible amount of imaging radiation dose which raises patient safety concern. Therefore, the goal of this project is to investigate and develop innovative, prior-image-based CBCT imaging techniques that can yield high quality images with reduced dose. During the first year of this project, The author has focused on investigation and development of prior image-based, narrowly collimated CBCT imaging technique. The author also started to investigate and develop total-variation-based image-reconstruction algorithms. In addition, the author has designed and developed software utilities and hardware devices necessary for the proposed experiments. In summary, during the first year, the author has successfully carried out research on the planned tasks, and the results obtained have formed a solid basis for the author to continue the research planned for the next year.