STUDIES ON THE HEMOGLOBIN-OXYGEN EQUILIBRIUM

摘要

Extent of "hybridization" between human adult and canine hemoglobins is highly dependent upon degree of oxygenation of the hemoglobins. A non-linear relationship was found between the extent of "hybridization" and that of oxygenation, which suggest that a non-straightforward alteration may occur in the quaternary structure of hemoglobin molecule upon the oxygen binding.nMutual ratio of the five hemoglobin fractions, was determined in five adult rats. No significant individual variation was observed for each of the five fractions in all the animals except the one in which one subcomponent was in a lowered level. (Author)