Toxicity Testing of Antimalarial Drugs in Swine. I. A Study of Quinine Sulfate Toxicity.

摘要

Quinine sulfate administered orally to swine in doses of 361 mg/kg/day (milligrams/kilograms/day) resulted in an LD 100/10 (Lethal dose 100/10), whereas, 180 mg/kg/day produced death in one of four pigs in 30 days, and no ill effects were observed in animals that received 45 mg/kg/day for 30 days. The most consistent symptoms observed were: emesis, depression, ataxia, partial to complete loss of sight and convulsions. The hematologic and biochemical results were very unimpressive, with few changes. The significant gross lesions may be summarized as: a hemorrhagic disorder, corneal lesions and alopecia. The most significant microscopic lesions are vacuolization of neurons, corneal lesions, bone marrow lesions and degenerative lesions of the arteriolar walls. Keywords: U/A Reports, Toxicity, Antimalarial, Drugs, Swine, Testing, Pharmacology, Quinine sulfate, Medical research. (jg)