Microbial Drug Resistance (Epidemiology, Genetics)

摘要

The strains of Staphylococcus aureus, Escherichia coli, Pseudomonous, Proteus and Klebsiella-Aerobactea, are isolated most frequently from clinical specimens, and should be noted that most of them are multiple-resistant to antibacterial agents that are generally used in hospitals. A collection has been made of many bacterial strains from patients at hospitals which are geographically dispersed in Japan. Their biological and biochemical properties have been studied according to the usual bacterial technics. Resistance to about 30 antibacterial agents was assayed, and biochemical and genetic studies of bacterial drug-resistance were conducted. This report has aimed specially on the problem of drug-resistance of staphylococci. Contents: Transduction analysis of the genetic determinants for antibiotic resistance in S. aureus; Lability of Streptomycin(SM) resistance in S. aureus; Macrolide resistance in S. aureus; Mechanisms of Tetracycline(TC) resistance in S. aureus. (Author)