Effects of Exposure to Monomethylhydrazine and 1,1-Dimethylhydrazine on the Immunological Responsiveness of Guinea Pigs.

摘要

The humoral immune response of guinea pigs was measured by determining serum antibody titers to bovine serum albumin. Cell mediated immunity was tested in vivo by evaluating the delayed hypersensitivity to tuberculin. Three compounds were tested. One, 6-mercaptopurine (6MP),was a known immunosuppressive drug. Its administration resulted in significantly depressed humoral and cellular responses,demonstrating that these methods could be used to evaluate immunosuppression in routine toxicity testing. Exposure to the two toxic rocket propellants monomethylhydrazine and 1,1-dimethylhydrazine resulted in a similar but less pronounced decrease in immune responsiveness. (Author)