Evaluation of Commercially Prepared Vaccines for Experimentally Induced Type A/NJ Virus Influenza Infections in Mice and Squirrel Monkeys.

摘要

Mice and squirrel monkeys were vaccinated and subsequently challenged at selected times in order to evaluate the immunoprophylactic value of vaccines against influenza virus type A/NJ. When challenged 17 or 60 days after vaccination with 80 CCA units of whole virus, mice showed minimum lesions and virus in lung tissue, and had lower lung weights than unvaccinated controls. These mice had serum HAI titers of >1:400, but only traces of antibody were found in lung washes. Vaccinated squirrel monkeys had significantly less illness than unvaccinated controls when challenged with virulent virus 30 days after i.m. immunization with 200 CCA units of whole virus or 400 CCA units of split virus given either once or twice (at 30-day intervals). Equal protection was observed in all monkeys.