Sleep EEG Power Spectral Profiles and Anticonvulsant Drugs: Comparison of Protective Effects with Monomethylhydrazine.

摘要

The effects of five known anticonvulsant compounds on electroencephalographic (EEG) power spectral density profiles during slow wave sleep were measured in a group of five chaired rhesus monkeys. Doses used corresponded to established clinical standard in children of similar weight to our primate subjects. Compared to saline controls, all five anticonvulsant drugs produced a specific pattern of spectral density change localized to sensorimotor cortex, bilaterally. This consisted of a sharp attenuation of activity below 7 Hz, and particularly in the 4-7 Hz band, and an increase and/or stabilization of power in the 12-15 Hz band. A second, identical test series was carried out with 15 mg/kg of monomethylhydrazine (MMH) administered shortly after drug injections. Significant protective effects were obtained with pyridoxine and diazepam but not with valproic acid or carbamazepine. Reference to the spectral density changes produced by these groups of drugs suggested that compounds which protect against MMH primarily attenuated 4-7 Hz activity in the sensorimotor EEG. This outcome was consistent with evidence for an acute increase in cortical neuronal hyperexcitability following MMH, and with data indicating a mediation of this effect by disturbances in the inhibitory functions of GABA. (Author)