Hematologic Characterization of Naturally Occurring Malaria (Plasmodium inui) in the Cynomolgus Monkey (Macaca fascicularis)

摘要

Forty-three percent of 47 recently imported cynomolgus monkeys (Macaca fascicularis) were found to have malarial infections. The agent identified was Plasmodium inui. All infections were subclinical in nature. Parasitemias ranged from 10-900 parasites/cm mm of whole blood. Pre- and posttreatment hematologic values were evaluated following treatment with chloroquine. Treatment was effective in clearing parasitemias from 13 of 14 infected monkeys. Pretreatment values of hematocrit, hemoglobin and mean corpuscular volume were significantly different in infected animals compared to noninfected animals. (Author)