Controlled Release of Antigens for One Dose Immunization.

摘要

The main objective of this study was to develop a biodegradable, controlled-release adjuvant system capable of eliminating the need for multistep vaccination schedules. This investigation was designed to: determine in an animal model hepatitis B vaccine release rate characteristics desirable for single-step immunization, incorporate those release rate characteristics into a one-step biodegradable poly(DL-lactide-co-glycolide) (DL-PLG) microencapsulated hepatitis B surface antigen (HBsAg) vaccine, and conduct an in vivo trial comparing the effectiveness of this single-step vaccine against the conventional three-step hepatitis vaccine currently employed. The results were intended to provide the foundation for further development of single step vaccines against hepatitis and other militarily significant diseases. Keywords: Pharmacology, Antigens, One-dose-immunization, Medicine, Vaccines. (jg)