Ion-Selective Electrodes for Some Beta-Adrenergic and Calcium Blockers

摘要

Potentiometric sensors based on dinonylnapthalene sulfonic acid (DNNS) were prepared for several recently developed drugs used in the treatment of cardiovascular disorders. Thus, incorporation of DNNS along with the beta-adrenergic blocker Acebutalol, or calcium-channel blockers Verapamil, Diltiazem, Nicardipine, or Lidoflazine into a plasticized polyvinyl chloride membrane resulted in coated-wire ion selective electrodes which displayed nearly Nernstian response in the concentration range of 10 to the minus 3 to 10 to the minus 5 M and analytically useful responses down to 10 to the minus 6 M. Selectivity behavior for each set of electrodes was accurately predicted from calculated distributon constants for the respective drugs. Use of these electrodes in analyses of pharmaceutical preparations is discussed, as well as their utility in pharmacokinetic studies. (Author)