Topical Hazard Evaluation Program of Hexahydro-1-((2-Methylcyclohexyl) Carbonyl)-1-H-Azepine (AI3-35770), US Department of Agriculture Candidate Insect Repellent

摘要

All sample batches of hexahydro-((2-methylcyclohexyl) carbonyl))-1-H-azepine, Candidate Insect Repellent AI3-35770, produced moderate to severe primary irritation of the intact skin and of the skin surrounding an abrasion. This lesion was characterized by a palpable thickening of the skin, hyperkeratosis, with eventual sloughing of the application site. Ethanol solutions of these chemicals were moderately irritating to the intact skin, and did not produce as severe a response as the technical chemicals. Washing the skin with soap and water, 6 hours after application, of either the technical chemical or ethanol solutions did not reduce the severity of dermal irritation.