Chemical and Molecular Biological Aspects of Alkylhydrazine-Induced Carcinogenesis in Human Cells in Vitro. Revised

摘要

The syntheses for 1,1-(methyl-14C)-dimethylhydrazine, 1,2-(methyl-14C)-dimethylhydrazine, and the important metabolite of 1,2-dimethylhydrazine, namley, 14C-methylazoxymethanol as an acetate derivative are described. Materials for high specific activity were employed to (1) Investigate early events in carcinogenesis; (2) Study DNA modification and damage; and (3) Probe effects of anticarcinogen benzamide, on molecular perturbation of DNA by methylazoxymethanol acetate.