Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography

摘要

A simple differential-pulse polarographic (D.p.p.) method has been developed for the analysis of minoxidil in pharmaceutical dosage forms. The extracting solvent was methanol and the supporting electrolyte was 1.0 N sulphuric acid. An excellent linear relationship was obtained between concentration and current peak height with a correlation coefficient of 0.9999. Good agreement was obtained between results with the d.p.p. method and those by the manufacturer's method of assay. There was no interference by the tablet excipients. In acid solution, a mechanism for reduction at -1.2 V is proposed which involves four electrons transferred as well as dehydration and deamination steps. (Author)