Experimental Pseudomonas aeruginosa Burn Infections

摘要

One of the organisms most frequently encountered by burn victims is Pseudomonas aeruginosa. The difficulty and ethical problems involved in studying patients with life-threatening infections have made it necessary to conduct evaluations of therapeutic approaches and the course of infections in a number of animal models. These models deal with particular diseases, microorganisms, or aspects of a given organism. Frequently, however, the trauma of the experimental burn or mechanical injury contributes significantly to the death of the animal, thus making difficult the evaluation of the parameters being studied. In this report, we describe a non-lethal burn in the mouse model (3-6), which mimics the human clinical situation and has been used extensively in studying p. aeruginosa virulence factors and various experimental p. aeruginosa vaccine preparations keywords: Virulence-enhancing factors, Exotoxin A, Virulence factor, Trauma.