Metabolic Changes Following Eccentric Exercise in Trained and Untrained Men

摘要

The effects of one 45 minute bout of high intensity eccentric exercise (250 Watts) were studied in 4 male runners and 5 untrained men. Plasma creatine kinase (CK) activity in these runners was high (p < 0.001) than in the untrained men before exercise and peaked at 207 IU/ml one day after exercise, while in untrained men the maximum was 2143 IU/ml five days after exercise. Plasma interleukin-1 (IL-1) in the trained men was also higher (p < 0.001) than in the untrained men before exercise but did not significantly increase after exercise. In the untrained men, IL-1 was significantly elevated 3 hours after exercise (p < 0.001). In the untrained group only, 24-hour urines were collected before and after exercise while the men consumed a meat-free diet. Urinary 3-methyl-histidine/creatinine in the untrained group rose significantly from 126 umol/g before exercise to 180 umol/g ten days after exercise. The results suggest that in untrained men, eccentric exercise leads to a metabolic response indicative of delayed muscle damage. Regularly performed long distance running was associated with chronically elevated plasma IL-1 levels and serum CK activities without acute increases after an eccentric exercise bout.