HMX: Toxicokinetics of (14)C-HMX Following Oral Administration to the Rat and Mouse and Intravenous Administration to the Rat

摘要

After an oral dose of 500 mg/kg to rats, 85% was eliminated in the faeces in 4 days. The equivalent figure for mice was 70%. Plasma and expired CO2 levels were very low. Intravenous administration to rats resulted on 61% being eliminated via the urine in 4 days. Peak plasma levels were achieved in 1 h and persisted for 6 h. There was significant and rapid metabolism to very polar metabolites. The above implies very poor absorption of HMX after oral dosing. Tissue levels were highest in the liver, kidney, and brain.