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Diagnosis and Management of Trichothecene Toxicosis in the Swine Model

机译:猪模型中单端孢菌毒素的诊断与治疗

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A single large dose of the water soluble of methyprednisolone significantly prolonged survival times in T-2 toxin-treated young female rats. The use of diltiazem hydrochloride, dazemgrel, N-acetylcysteine, dimethyl sulfoxide, adenosine triphosphate (ATP), ATP combined with magnesium chloride, ascorbic acid, trichodermin, and aprotinin did not prolong survival times at the dosages administered. PGE, at 50 ug/kg given by slow i.v. infusion did not improve survival times. The combination of dexamethasone (DEX) and PGE, did improve survival times compared with the control group of animals receiving T-2 toxin and no therapy, however, the improvement in survival time was no better than that obtained with DEX alone. Keywords: Trichothecene, Toxins, Diacetoxyscirpenol, Path physiology, Therapy, Hisopathology, Physiology, Inhalations, Skin, Metabolism, Analysis, Production.

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