Immunomodulation by Proteins of Bordetella pertussis

摘要

Endotoxin associated proteins (EP) from Bordetella pertussis and Salmonella typhi have been found to be potent immunomodulators. EP is an adjuvant for T-dependent and T-independent antigens. Both the primary and secondary antibody responses to T-dependent antigens are enhanced. T-cells and macrophages act as accessory cells in this adjuvant effects; however, a significant portion of the enhanced antibody response to any one antigen is due to polyclonal activation by EP. In addition EP activates macrophages to produce the lymphokine Interleukin-1 which may play a role in the adjuvant effect as well. Finally, lipopolysaccharide endotoxin derived from Bordetella pertussis has been found to activate the B-cells and macrophages of C3H/HeJ mice which are hyporesponsive to LPS endotoxin from enteric Gram-negative bacteria.