Effect of Dehydration on Cardiovascular Responses and Electrolytes Following Hypertonic Saline Dextran Treatment for Moderate Hemorrhage.

摘要

The efficacy of hypertonic saline/dextran (HSD) for treating hemorrhage in the presence of dehydration was evaluated in conscious swine. Following surgical preparation, animals were euhydrated or dehydrated for 24 hr or 48 hr. Dehydration resulted in a reduction in body weight and increased plasma osmolality and sodium levels, but did not alter plasma volume. Animals were bled 25 ml/kg/60 min and treated with HSD (4 ml/kg/1 min, 7.5% NaCl and 6% Dextran 70). HSD immediately rectified the decreases in mean arterial pressure and cardiac output incurred during hemorrhage. There were parallel increases in plasma osmolality and sodium concentrations which were offset by the initial differences due to dehydration. All groups showed equivalent decreases in hematocrit, hemoglobin and protein. Given these results, we concluded that dehydration does not compromise the efficacy of HSD as a resuscitation treatment for hemorrhagic shock. Keywords: Hemorrhage, HSD, Dehydration, Plasma osmolality, Sodium concentrations, Hemorrhagic shock. (sdw)