Hypertonic Saline Solution Reduces Oxidative Stress and Liver Damage After 6h Treatment of Hemorrhagic Shock

摘要

Oxidative stress plays an important role in the development of microvas-cular injury associated with ischemia and reperfusion. After ischemia, the reoxygenation may aggravate the injury caused by the ischemic process itself, since radical oxygen species (ROS) react with cell membranes with consequent lipid peroxidation and cell death.Resuscitation with Hypertonic Saline Solution (HSS -^sNaCl 7,5%) after hemorrhagic shock (HS) leads to acute recovery of both macro and microhemodynamics, improving immunomodulation and microvascular perfusion, allowing a reduction of the deleterious effects of the ischemia/reperfusion (I/ R) in the liver microcirculation. On the other side, the low osmolarity and high volumes of Ringer Lactate (RL) resuscitation promote fluid movements to the third space and tissue edema is a common complication. Moreover, large volumes of RL replacement can be even deleterious, resulting in worsening of the tissular oxygenation and perfusion.Aim of the study was compare the late effects (after 6 hours) of resuscitation with NaCl 7,5% solution or Ringer Lactate (RL) on hepatic function, integrity and oxidative stress.