Use of Substituted Pentamethylpyrromethene-Boron Difluoride Complexes in Photodynamic Therapy.

摘要

A series of pentamethylpyrromethene boron difluoride (PMP-BF2) complexes are described which have extremely efficient lasing properties and are active in cancer photodynamic therapy (PDT). The most derivative tested was the disodium salt of PMP-BF2-2, 6-disulfonate (PMP-BF2-DS). Cells from a human ovarian cancer cell line (LS-2) were incubated with PMP-BF2-DS for 30 min. and then the cells were washed. The cells were resuspended in RPMI media and irradiated with a quartz lamp for 10-20 min. When compared to controls (only light for only chemical) there was a 100% inhibition of cellular growth. Reprints.