Neurobehavioral Effects of Carbon Monoxide (CO) Exposure in Humans: Elevated Carboxyhemoglobin (COHb) and Cerebrovascular Responses.

摘要

A two-channel cranial impedance plethysmograph (CIP) was designed and constructed as a noninvasive measure of brain blood flow (BBF) in man. The instrument was designed to reduce some of the problems with instability and difficulty of use found in earlier commercially-available models. The CIP has been previously validated against other measures of BBF. During carboxyhemoglobin (COHb) formation, BBF is known to increase. When BBF increases it compensates for the reduced ability of the blood to carry oxygen in the presence of COHb. Fifteen men breathed carbon monoxide (CO) to produce increases in COHb values ranging from endogenous 18.4%. Keywords: Carbon monoxide, CO, Carboxyhemoglobin (COHb), Toxicity, Brain blood flow, Cerebrovascular. (JES)