Antibodies to Liposomes, Phospholipids, and Cholesterol, Implications for Autoimmunity, Atherosclerosis and Aging.

摘要

It is often stated that lipids are are nonimmunogenic; however, this idea is now known to be a false presumption. Polyclonal antibodies having considerable specificity for individual phospholipid constituents of liposomes have now also been developed (Wassef et al., 1989; Banerji and Alving, 1989). After developing immunoassay procedures (complement-dependent assays and solid-phase immunosorbent assays) for detecting antibodies to lipids, we and others discovered that naturally-occurring autoantibodies to various phospholipids are widespread and occur in most adult animal or human sera. (JES)