Multivesicular liposomes: effects of cholesterol level and phospholipid acyl chain length on stability

摘要

Multivesicular liposomes are typically preparedwith over 50 mol % cholesterol, and with phospholipidacyl chains of 16-18 carbons. Here we show thatMVL can be prepared without cholesterol. MVLprepared with low proportions of cholesterol areunstable; their stability can be increased somewhatby using longer unsaturated phosphatidylcholines.